Preclusion of evidence
Two corrupt federal investigators (now in prison) with unfettered access to Silk Road, stole over $1 million from the site. The prosecution aggressively moved to keep any reference to them, or to their activities, hidden from the jury.
This was in direct violation of the Brady Rule, an established law that states evidence favorable to a defendant is not allowed to be hidden.
Read more at Evidence Hidden From Jury.
Uncharged, unproven allegations
The government used uncharged, unproven murder-for-hire allegations to deny Ross bail, smear him in the media, bias his jurors, and justify the life sentence he ultimately received.
Although the government did not charge Ross for murder-for-hire at trial, Judge Forrest permitted the prosecution to speak at length about these uncharged crimes, despite protest from the defense that this would prejudice the jury and the public.
Read more at Making A Murderer.